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Einleitung Trichotillomanie (TTM) bezeichnet repetitives Haareusreißen, das beträchtliches Leiden hervorruft oder zu einer signifikanten Funktionseinschränkung führt. Diese Störung gilt als Impulskontrollstörung, ist aber aufgrund von Ähnlichkeiten auch dem Zwangsstörungsspektrum zugeordnet worden. Bei Zwangsstörungen (ZS) deuten Studienergebnisse auf kognitive Funktionsstörungen hin, v.a. Beeinträchtigungen in der Unterdrückung von Gedanken und exekutive Funktionsstörungen. Die vorliegende Forschungsarbeit geht der Frage nach, ob TTM auch durch Auffälligkeiten in kognitiven Funktionen gekennzeichnet ist und ob diese störungsspezifisch sind. Aufgrund des Störungsbildes erscheint es naheliegend, (1) die Fähigkeit zur intentionalen Impulskontrolle bei TTM zu ...
Acute haemodynamic effects of optimizing the A-V interval with impedance cardiography in dual-chamber stimulation Background: Optimizing the A-V interval in dual-chamber stimulation may improve haemodynamics. Haemodynamic evaluation can be conducted by invasive or non-invasive procedures. One possible method is impedance cardiography, in which changes in cardiac volumes are recorded. The objective of this study was to analyze the acute haemodynamic effects of A-V intervals programmed at different lengths in dual-chamber stimulation, ascertained by determining stroke volume with impedance cardiography. Methods: The study was carried out with 42 patients who had a dual-chamber pacemaker or dual chamber ICD implanted, and the A-V interval was optimized by impeda...
Bei der Passage durch den männlichen Reproduktionstrakt interagieren Spermatozoen mit Faktoren, die u.a. vom Nebenhoden sezerniert werden. Die daraus resultierende Modifikation der Spermatozoen ist essentiell für die Ausreifung zu voll funktionsfähigen Keimzellen. Bei der Ausdifferenzierung im Nebenhoden spielen vermutlich u. a. auch die Epididymosomen (apokrin sekretierte Nebenhodenvesikel) eine wichtige Rolle. In vorausgehenden Untersuchungen unserer Arbeitsgruppe konnte gezeigt werden, dass sich die Plasmamembran-Ca2+-ATPase Isoform 4 (PMCA4) Spleißvarianten-Ausstattung in der Membran von Bullenspermien von PMCA4b in Caputspermien zu PMCA4a in Caudaspermien ändert. Zudem nahm auch die Ca2+-ATPase Aktivität der Spermien während der Passage durch den Nebenho...
Background: Presently, there is a worldwide attempt to further decrease abdominal trauma and optimize the cosmetic results after laparoscopic cholecystectomy. In a prospective observational study, the combined suprapubic and intraumbiilical cholecystectomy in Minden modification (MI- CHE) was evaluated. Method: The MI- CHE is performed via a 5mm intraumbilical trocar through which a 30° optic is introduced. A 10 mm trocar that is later used as a camera port for the long 45° laparoscopic optic is then instilled in the suprapubic area under visual control, alongside of a long curved grasper. An auxiliary instrument may be punctured into the right abdominal flank without a trocar. Retrieval of the gall bladder is carried out through the suprapubic incision. Pati...
The thesis at hand uses the example of three different target proteins to describe struc-ture-based design of drugs, the first being HIV-1 protease, the second and third being the human proteins transglutaminase 2 and coagulation factor XIII. The aim of this the-sis was to crystallize the respective proteins in complex with their inhibitors and to de-termine the three-dimensional structure of the complexes by X-ray analysis. The result-ing information about the binding mode of the inhibitors could then be used for the de-sign of new molecules and the optimization of binding properties, for example the affin-ity to the protein. In this way, a contribution to the development of new drugs has been made. Inhibitors of HIV-1 protease are potential drugs for the ...
Hartmut Esser’s integrative social theory – Potentials of explanation and understanding The article provides an introduction of the integrative social theory of Hartmut Esser. Herewith, Esser intends to overcome the fragmentation of sociology into different paradigms. The “model of sociological explanation” serves as the central instrument for achieving this integrative project. It provides the framework for understanding and explaining the processing of social aggregation dynamics. The article elaborates on the premises, backgrounds, and analytical steps of the “model of sociological explanation”.
This contribution presents the findings of an investigation of the competences, levels of performance and progress of students who were enrolled in German as a Foreign Language (GFL) courses within the Public Relations program at the University of Udine (Italy). Besides domain-specific, methodological, personal and socio-communicational as well as linguistic and culture-specific competences, the intercultural competence and competence awareness are highlighted. The data gathered during two academic years are performance- and process-oriented. They have been analyzed on the basis of a multi-perspective approach. The Kassel-Competence-Grid served as a diagnostic instrument for competence evaluation in professional settings. In order to assess the students’ ...
This article provides some details on the research questions in connection with the epistemic interests of our investigation. The questions, basically, refer to the evaluation of pre-service teacher students’ pedagogical diagnostic competences and to the competence model needed for the evaluation as well as to the impact of feedback on students’ competence development. Here, pedagogical diagnostic competence is conceived as a primary competence of all kinds of teaching, which enables professionals to determine the context factors (situations, processes, effects) and their complex interdependencies within the contexts of schooling and classroom activities. Further purposes of the development of the competence model aim at making a difference between more or le...
Weltweit werden Wälder in alarmierender Geschwindigkeit zerstört und fragmentiert. Landschaften bestehen zunehmend aus Mosaiken mit Waldfragmenten in variablem Matrixhabitat. Es ist daher essentiell zu verstehen, inwiefern diese Habitatveränderungen Funktion und Stabilität von Waldökosystemen beeinflussen. Die komplexen Zusammenhänge zwischen anthropogener Störung von Wäldern, Artenverlust und Ökosystemfunktionen sind jedoch noch nicht hinreichend geklärt. In der vorliegenden Arbeit untersuchte ich den Einfluss von Waldfragmentqualität und Matrixhabitat auf Biodiversität und ökologische Prozesse der Waldregeneration. Ich führte drei Studien in einer fragmentierten Waldlandschaft in KwaZulu-Natal, Südafrika durch. Ich erfasste 1) Samenprädation durch Nager, 2)...
Purpose: We evaluated haematopoietic reconstitution including engraftment of white blood cells (WBC) and platelet cells (PLT) and supportive care requirements including red blood cell concentrates (RBCC), single-donor platelet concentrates (PLTC), antibiotical and antifungal treatment, as well as hospital stay and fever days in patients undergoing autologous transplantation after tandem highdose chemotherapy by multiple myeloma. Methods: Patients (n=44, 19 women, 25 men) suffering multiple myeloma (28 stage III, 14 stage II, 2 stage I by Durie and Salmon) underwent tandem HDCT/ASCT. We determined the days of engraftment of WBC and PLT as well as the number of transfused RBCC and PLTC, the number of patient-days on intravenous (i.v.) antibiotics and i.v. ...
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