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Cells exhibit propagating membrane waves which involve the actin cytoskeleton. One type of such membranal waves are Circular Dorsal Ruffles (CDR) which are related to endocytosis and receptor internalization. Experimentally, CDRs have been associated with membrane bound activators of actin polymerization of concave shape. We present experimental evidence for the localization of convex membrane proteins in these structures, and their insensitivity to inhibition of myosin II contractility in immortalized mouse embryo fibroblasts cell cultures. These observations lead us to propose a theoretical model which explains the formation of these waves due to the interplay between complexes that contain activators of actin polymerization and membrane-bound curved proteins of both types of curvature (concave and convex). Our model predicts that th...
Muons from cosmic-ray interactions in the atmosphere provide a high-statistics source of particles that can be used to study the performance and calibration of the ATLAS detector. Cosmic-ray muons can penetrate to the cavern and deposit energy in all detector subsystems. Such events have played an important role in the commissioning of the detector since the start of the installation phase in 2005 and were particularly important for understanding the detector performance in the time prior to the arrival of the first LHC beams. Global cosmic-ray runs were undertaken in both 2008 and 2009 and these data have been used through to the early phases of collision data-taking as a tool for calibration, alignment and detector monitoring. These large datasets have also been used for detector performance studies, including investigations that rel...
HIV infection is pandemic in humans and is responsible for millions of deaths every year. The discovery of new cellular targets that can be used to prevent the infection process represents a new opportunity for developing more effective antiviral drugs. In this work, dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN), a lectin expressed at the surface of immature dendritic cells and involved in the initial stages of HIV infection, is described as a promising therapeutic target. The project is being developed within the European research Network CARMUSYS (http://www.carmusys.iiq.csic.es). Herein we show the synthesis of a small library of derivatives of a dimannoside mimic recently reported by our laboratory.1 The mimic was functionalized with two identical amide groups. Further, multivalent presentations of the prepared DC-...
In this paper, the use of an evolutionary approach when obtaining linguistic summaries from time series data is proposed. We assume the availability of a hierarchical partition of the time dimension in the time series. The use of natural language allows the human users to understand the resulting summaries in an easy way. The number of possible final summaries and the different ways of measuring their quality has taken us to adopt the use of a multi objective evolutionary algorithm. We compare the results of the new approach with our previous greedy algorithms.
A search is made for massive long-lived highly ionising particles with the ATLAS experiment at the Large Hadron Collider, using 3.1 pb-1 of pp collision data taken at sqrt(s)=7 TeV. The signature of energy loss in the ATLAS inner detector and electromagnetic calorimeter is used. No such particles are found and limits on the production cross section for electric charges 6e <= |q| <= 17e and masses 200 GeV <= m <= 1000 GeV are set in the range 1-12 pb for different hypotheses on the production mechanism.
This Letter presents the first search for supersymmetry in final states containing one isolated electron or muon, jets, and missing transverse momentum from sqrt{s} = 7 TeV proton-proton collisions at the LHC. The data were recorded by the ATLAS experiment during 2010 and correspond to a total integrated luminosity of 35 pb-1. No excess above the standard model background expectation is observed. Limits are set on the parameters of the minimal supergravity framework, extending previous limits. For A_0 = 0 GeV, tan beta = 3, mu > 0 and for equal squark and gluino masses, gluino masses below 700 GeV are excluded at 95% confidence level.
The inclusive J/psi production cross-section and fraction of J/psi mesons produced in B-hadron decays are measured in proton-proton collisions at sqrt(s) = 7 TeV with the ATLAS detector at the LHC, as a function of the transverse momentum and rapidity of the J/psi, using 2.3 pb-1 of integrated luminosity. The cross-section is measured from a minimum pT of 1 GeV to a maximum of 70 GeV and for rapidities within |y| < 2.4 giving the widest reach of any measurement of J/psi production to date. The differential production cross-sections of prompt and non-prompt J/psi are separately determined and are compared to Colour Singlet NNLO*, Colour Evaporation Model, and FONLL predictions.
This paper describes searches for the pair production of first or second generation scalar leptoquarks using 35/pb of proton-proton collision data recorded by the ATLAS detector at sqrt(s)=7 TeV. Leptoquarks are seached in events with two oppositely charged muons or electrons and at least two jets, and in events with one muon or electron, missing transverse momentum and at least two jets. After event selection, the observed yields are consistent with the predicted backgrounds. Leptoquark production is excluded at the 95% CL for masses mLQ<376 (319) GeV and mLQ<422 (362) GeV for first and second generation scalar leptoquarks, respectively, when assuming the branching fraction of a leptoquark to a charged lepton is equal to 1.0 (0.5).
A search for contact interactions has been performed using dimuon events recorded with the ATLAS detector in proton-proton collisions at sqrt(s) = 7 TeV. The data sample corresponds to an integrated luminosity of 42 pb-1. No significant deviation from the Standard Model is observed in the dimuon mass spectrum, allowing the following 95% C.L. limits to be set on the energy scale of contact interactions: Lambda > 4.9 TeV (4.5 TeV) for constructive (destructive) interference in the left-left isoscalar compositeness model. These limits are the most stringent to date for mumuqq contact interactions.
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