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The idea that the apparently random motion of T cells in lymph nodes is a result of movement on a reticular network (RN) has received support from dynamic imaging experiments and theoretical studies. We present a mathematical representation of the RN consisting of edges connecting vertices that are randomly distributed in three-dimensional space, and models of lymphocyte movement on such networks including constant speed motion along edges and Brownian motion, not in three-dimensions, but only along edges. The simplest model, in which a cell moves with a constant speed along edges, is consistent with mean-squared displacement proportional to time over intervals long enough to include several changes of direction. A non-random distribution of turning angles is one consequence of motion on a preformed network. Confining cell movement to ...
ABSTRACT This paper is concerned in general with the intersection of cognitive and clinical science and in particular with schema theory. The use of schema theory in the various subdisciplines of cognitive science, as well as by cognitive-behavioral clinicians and psychoanalytically oriented clinicians is reviewed. It is argued that schema theory, in both cognitive and clinical sciences, allows a focus on mental structures their biological basis, their development and change, and on the way in which they direct psychological events. Schema theory not only enables important advances in different clinical schools, but it allows central clinical themes to be tackled in convergent ways. It is concluded that the schema construct allows integration within cognitive science, within the clinic, and between the two.
ABSTRACT Cognitive science is a multidisciplinary field, comprising cognitivepsychology, artificial intelligence, linguistics, neuroscience, and anthropology. In recent years, cognitive science has become a predominant paradigm in studies of the mind. This paper reviews work at the emerging interface between cognitive science and psychiatry. It is argued that cognitive science has significant potential as an integrative framework for theorizing and researching psychiatric disorders and their treatment.
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