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Main urinary bacterial metabolites of phenylalanine (total benzoic and phenylacetic acids) and of tyrosine (total p-hydroxybenzoic acid and p-hydroxyphenylacetic acid) were determined by gas chromatography in controls and patients with cystic ubrosis of the pancreas, coeliac disease, intestinal resection and unclassified enteritis. In various patients, especially in the untreated coeliacs, high amounts of one or more of the abovementioned metabolites were found. In this paper results in controls and patients are presented and discussed.
In 26 out of a large group of patients with gastrointestinal disorders abnormal urinary imidazole excretion patterns were found. Most frequently excessive or increased amounts of imidazolepropionic acid (ImPA) occurred, and as next N-acetylhistamine was excreted in excess. In a number of cases the latter was accompanied by a substance identified as N-propionylhistamine. It is suggested that these excretory products are bacterial metabolites of histidine, if not absorbed in the intestinal lumen. All 26 patients excreted increased amounts of bacterial metabolites of tyrosine and/or phenylalanine as well: p-OH-phenylacetic and/or p-OH-benzoic acids and phenylacetic and/or benzoic acids respectively. Many patients showed increased urinary 4-amino-5-imidazolecarboxamide, its riboside and an unknown related compound X, especially in a late...
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