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This thesis aimed to gain new insights regarding the course and prognosis of uveitis in childhood, the pathogenesis of JIA-uveitis and the treatment of uveitis in children. The role of baseline prognostic factors in JIA-uveitis was studied by a retrospective analysis of 117 affected eyes of 65 patients with JIA-uveitis. Male gender is associated with a complicated course and poor visual prognosis in JIA-uveitis. Uveitis as initial manifestation of JIA is associated with development of posterior synechiae. We investigated the course of JIA-uveitis in a retrospective analysis of 62 patients with JIA-uveitis. High uveitis activity was found at 4-6 years of age, followed by a quiet stage around the age of 9 and 10, after which activity rose again. Administration of systemic medication also increased with age. We attempted to answer the...
The aim of this study was to gain more insight into the development of complications in childhood uveitis and to evaluate the treatment options for these mostly sight-threatening conditions with emphasis on juvenile idiopathic arthritis (JIA)-associated uveitis. The second aim was to investigate which cytokines are involved in the pathogenesis of pediatric uveitis by analyzing the presence of immune mediators in the aqueous humor of children suffering from this disease. To pursue the aim of this thesis we performed several retrospective studies and two clinical laboratory investigations (multiplex immunoassay). The conclusion to our investigation in this thesis is that of all children with uveitis, those with JIA are at greatest risk of developing secondary glaucoma. When glaucoma surgery is required, we found that the implantation of ...
Uveitis is an inflammation of the inner-eye and is initiated by various infectious and noninfectious causes. In a large portion of patients the etiology is unknown and might be associated with until now undiagnosed infections.The identification of infectious uveitis is of crucial importance since its treatment and visual prognosis differ entirely from noninfectious inflammations. For the definitive diagnosis of infectious uveitis analysis of intraocular fluid, aqueous humor or vitreous fluid, is essential. The aim of this thesis was to discover novel causes of infectious uveitis by analysis of intraocular fluids using real-time PCR and the detection of intraocular antibody production and to gain more insight into the (immuno)-pathogenesis of infectious uveitis. Analysis of intraocular fluids from patients with idiopathic anterior uveit...
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