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Background and objective: Patients are increasingly requiring their medications to be repackaged into dose administration aids because of the positive outcomes associated with reduction in medication related hospitalization and adverse effects due to improved medicines management. Since the stability of these repackaged medications is not the responsibility of manufacturer, it is important that drug substances with potential stability issues be identified. Thus the objective of this study was to evaluate the stability of prochlorperazine, a light sensitive drug repackaged into dose administration aids (DAAs), in order to provide guidelines to the pharmacist and advice to the patient on appropriate storage. Methods: Prochlorperazine tablets were stored repackaged in DAAs and in their original packaging for 8 weeks at ambient (25 ± ...
Background and objective: Patients are increasingly requiring their medications to be repackaged into dose administration aids because of the positive outcomes associated with reduction in medication related hospitalization and adverse effects due to improved medicines management. Since the stability of these repackaged medications is not the responsibility of manufacturer, it is important that drug substances with potential stability issues be identified. Thus the objective of this study was to evaluate the stability of prochlorperazine, a light sensitive drug repackaged into dose administration aids (DAAs), in order to provide guidelines to the pharmacist and advice to the patient on appropriate storage. Methods: Prochlorperazine tablets were stored repackaged in DAAs and in their original packaging for 8 weeks at ambient (25 ± ...
[Extract] Mebendazole, methyl 5-benzoyl benzimidazole-2-carbamate, a broadspectrum anthelmintic drug exists in three polymorphic forms (A, B, C) with different solubilities and thermodynamic stabilities [1]. Due to its poor solubility, the more soluble, but less stable Form C is therapeutically favoured in drug formulations such as suspensions [2]. The objectives of this work were to develop simple, direct and non-destructive procedures to identify and quantify crystal purity of mebendazole raw material and to establish stability of the preferred Form C in a suspension formulation.
The objective of this study was to develop a simple, direct and non-destructive method to assess crystal purity of mebendazole raw material and to establish its stability in a suspension formulation using diffuse reflectance ultraviolet (DRA-UV) spectroscopy and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy. Quantitation of mebendazole, found to exhibit polymorphism with three polymorphic forms A, B and C identified, was carried out with ATR-FTIR spectroscopy. Artificial neural network (ANN) was employed as a data-modelling tool. The developed ANN models confirmed that the characteristic absorptions in the infrared (IR) spectral region are directly proportional to the measured amounts of mebendazole crystal forms present in the samples (r2 > 0.94), which was confirmed with X-ray diffraction (XRD) at r2...
[Extract] Mebendazole, methyl 5-benzoyl benzimidazole-2-carbamate, a broadspectrum anthelmintic drug exists in three polymorphic forms (A, B, C) with different solubilities and thermodynamic stabilities [1]. Due to its poor solubility, the more soluble, but less stable Form C is therapeutically favoured in drug formulations such as suspensions [2]. The objectives of this work were to develop simple, direct and non-destructive procedures to identify and quantify crystal purity of mebendazole raw material and to establish stability of the preferred Form C in a suspension formulation.
The objective of this study was to develop a simple, direct and non-destructive method to assess crystal purity of mebendazole raw material and to establish its stability in a suspension formulation using diffuse reflectance ultraviolet (DRA-UV) spectroscopy and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy. Quantitation of mebendazole, found to exhibit polymorphism with three polymorphic forms A, B and C identified, was carried out with ATR-FTIR spectroscopy. Artificial neural network (ANN) was employed as a data-modelling tool. The developed ANN models confirmed that the characteristic absorptions in the infrared (IR) spectral region are directly proportional to the measured amounts of mebendazole crystal forms present in the samples (r2 > 0.94), which was confirmed with X-ray diffraction (XRD) at r2...
Mebendazole, a broad spectrum anthelmintic drug, exists in three polymorphic forms (A, B and C) with differing solubilities and rates of dissolution. The order of solubility is B>C>A. with polymorph B, seven times more soluble than A, while the order of stability is A>C>B. The fact that different therapeutic outcomes have been attributed to the different polymorphs supports the fact that low solubility and rate of dissolution are important factors to consider. The objective of this study was to develop a simple non-destructive method to test the crystal purity of the mebendazole raw material (bulk drug), and thus ensure that the pharmaceutically favoured polymorph C is present in both tablet and liquid dosage forms. A Diffuse Reflectance Infrared Fourier Transform (DRIFT) spectrometry method was developed for detection of the unfavoura...
Omeprazole, commonly used in the treatment of various gastrointestinal disorders degrades rapidly in acidic pHs and results in inter-individual variability due to different rates of metabolism amongst patients. Since S-omeprazole shows more predictable bioavailability and excipients have been known to interact with active pharmaceutical ingredients to produce altered bioavailability, it was decided to investigate the compatibility of omeprazole sodium isomers with mannitol, the major excipient in omeprazole formulations using differential scanning calorimetry (DSC) for bulk drug, attenuated total reflectance (ATR) infrared (IR) spectroscopy in a powder mixture and localized thermal analysis (LTA) from a drug disk. DSC results clearly indicate an interaction between mannitol and R-omeprazole sodium due to decreased melting temperatur...
The Gene Expression Database (GXD) is a community resource that stores and integrates expression information for the laboratory mouse, with a particular emphasis on mouse development, and makes these data freely available in formats appropriate for comprehensive analysis. GXD is implemented as a relational database and integrated with the Mouse Genome Database (MGD) to enable global analysis of genotype, expression and phenotype information. Interconnections with sequence databases and with databases from other species further extend GXD's utility for the analysis of gene expression data. GXD is available through the Mouse Genome Informatics Web Site at http://www.informatics.jax.org/
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