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This dissertation tests the hypothesis of differential fertility of Hb AS females in a malarial environment. The biocultural factors that affect achieved reproduction in this sample are examined. The aim of the research is to document the action of natural selection through differential fertility, and the interaction of culture and biology to produce achieved fertility. Epidemiological, clinical and in vitro studies indicate that Hb AS individuals experience low malarial morbidity and mortality. Thus, natural selection increases the frequency of hemoglobin S through differential mortality when the selective agent is malaria. However, it has also been proposed (Livingston, 1957) that the high frequency of hemoglobin S in malarial environments may be the result of differential mortality and reproduction. Pirscheinfs work (1961, 1984) sug...
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