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Histone acetyltransferases (HATs) and histone deacetylases (HDACs) mediate acetylation and deacetylation of histone proteins and transcription factors. There is abundant evidence that these enzymes regulate the acetylation state of many cytoplasmic proteins, including lysine residues in important metabolic enzymes. Lysine acetylation regulates major cellular functions as a common post-transcriptional modification of proteins, conserved from prokaryotes to humans. In this article, we refer to HATs and HDACs broadly as lysine acetyltransferases (KATs) and deacetylases (KDACs). Lysine acetylation is vitally important in both immunological and metabolic pathways and may regulate the balance between energy storage and expenditure. Obesity, type II diabetes and cardiovascular disease (metabolic syndrome) are widely recognised as featur...
We analyze an interdiction problem in which a nuclear-material smuggler can traverse the rail and road ports of entry (POEs) along the Mexican and Canadian borders of the United States. Our objective is to determine the optimal locations of a limited number of transparent and non-transparent assets so as to minimize the smuggler’s total probability of evasion, from origin to destination. We choose origins in Mexico and Canada and give the smuggler a diverse set of destinations to choose from. Our analysis aims to provide a complete prioritization and picture of the threat at Mexican and Canadian POEs, leading to insight into practical locations for transparent and non-transparent assets.
The birth of a child is a life-changing event in a woman's life. However, women's subjective experiences of giving birth have not been extensively researched, while the literature reflects an inherent realist approach. This has resulted in a decontextualised account of this critical event in women's lives. This conceptual study discusses the body of knowledge on the birthing experience from a widened perspective that includes not only the birthing woman, but also the people she interacts with and the context in which birth is embedded. The study comments on the way birth is managed in technological society and how its inherent Newtonian epistemology impacts on a woman's experience of birth. Ecosystemic epistemology is presented as an alternative approach which provides an holistic understanding of this experience. A reconceptualisation...
The aim of the study was to provide a quantitative means of investigating the prespeech vocalizations of babies with cleft palate. Because prespeech vocalizations appear to play an important role in the acquisition of language, it is vital to have a means of identifying these vocalizations beyond the phonemic inventory which omits potentially important vocal behavior. Acoustic analysis can supplement phonetic analysis and both measures may be utilized to identify communicative abilities of these babies at an early age.
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