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Comment: To be published in the proceedings of DPF-2009, Detroit, MI, July 2009, eConf C090726
Comment: 14 pages, 9 postscript figues, contributed to the proceedings of La Thuile 2001. Fixed Postscript problems
Comment: v2 corrects the affiliation of M. Convery
Comment: 36 pages, submitted to Nuclear Instruments and Methods A
Widespread thrombi are found among donor lungs rejected for transplantation. The 4G/5G polymorphism in the plasminogen activator inhibitor (PAI-1) gene impacts transcription and the 4G allele is associated with increased PAI-1 levels. We hypothesized that the 4G/4G genotype would be associated with decreased lung graft utilization, potentially because of worse oxygenation in the donor. We genotyped donors managed by the California Transplant Donor Network from 2001 to 2008 for the 4G/5G polymorphism in the PAI-1 gene. Non-Hispanic donors from 2001 to 2005 defined the discovery cohort (n = 519), whereas donors from 2006 to 2008 defined the validation cohort (n = 369). We found, that the odds of successful lung utilization among Non-Hispanic white donors were lower among donors with the 4G/4G genotype compared to those without this genot...
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