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The mouse strains BALB/cHeA (BALB/c) and STS/A (STS) are susceptible and resistant to Leishmania major-induced disease, respectively. We analyzed this difference using recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% genes of the strain STS in a BALB/c background. Previously, testing the resistant strain CcS-5, we found five novel Lmr (Leishmania major response) loci, each associated with a different combination of pathological and immunological reactions. Here we analyze the response of RC strain CcS-16, which is even more susceptible to L. major than BALB/c. In the (CcS-16 × BALB/c)F2 hybrids we mapped three novel loci that influence cutaneous or visceral pathology. Lmr14 (chromosome 2) controls splenomegaly and hepatomegaly. On the other hand Lmr15 (chromosome 11) determines h...
Department of Otorhinolaryngology, Head and Neck Surgery and Leuven Cancer Institute Department of Head and Neck Oncology and Radiotherapy, The Netherlands Cancer Institute, Amsterdam, the Netherlands Department of Otorhinolaryngology, Head and NEck Surgery and Radiotherapy, University Medical Center Utrecht, Utrecht, the Netherlands Dutch Head and Neck Oncology cooperative group
The branching ratio for the leptonic decay of charged B mesons (B- → tau (-)[([nu])over bar](tau)) has been measured using selected leptonic tau (-) → l(-)nu (tau)[([nu])over bar](l) and hadronic tau (-) → nu X-tau decays in Z → b (b) over bar decays recorded by DELPHI at LEP1 in 1992-1995. The result, BR(B- → tau (-)[([nu])over bar](tau)) lt 1.1 x 10(-3) at the 90% confidence level, is consistent with standard model expectations and puts a constraint on the ratio tan [beta]/MH+/- lt 0.46 (GeV/c(2))(-1) in the framework of models with two Higgs doublets (type II Higgs doublet model). From the missing energy distribution in Z → b (b) over bar decays without identified leptons, the b → tau[([nu])over bar]X-tau branching ratio has been measured in the hadronic channel tau - → nu X-tau'. The result, BR(b → tau[([nu])over bar]X-tau) = (...
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