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Background: the role of IgE in patients with severe asthma is not fully understood. Objective: we sought to investigate whether IgE to Staphylococcus aureus enterotoxins might be relevant to disease severity in adult asthmatic patients. Methods: specific IgE antibody concentrations in serum against enterotoxins, grass pollen (GP), and house dust mite allergens and total IgE levels were measured in adult cohorts of 69 control subjects, 152 patients with nonsevere asthma, and 166 patients with severe asthma. Severe asthma was defined as inadequately controlled disease despite high-dose inhaled corticosteroids plus at least 2 other controller therapies, including oral steroids. Results: enterotoxin IgE positivity was significantly greater in patients with severe asthma (59.6%) than in healthy control subjects (13%, P < .001). Twe...
We report on the successful sounding rocket flight of the high resolution (R=3000-4000) J-PEX EUV spectrometer. J-PEX is a novel normal incidence instrument, which combines the focusing and dispersive elements of the spectrometer into a single optical element, a multilayer-coated grating. The high spectral resolution achieved has had to be matched by unprecedented high spatial resolution in the imaging microchannel plate detector used to record the data. We illustrate the performance of the complete instrument through an analysis of the 220-245A spectrum of the white dwarf G191-B2B obtained with a 300 second exposure. The high resolution allows us to detect a low-density ionized helium component along the line of sight to the star and individual absorption lines from heavier elements in the photosphere.
We discuss the comprehensive analysis of spectrophotometric time-series observations of the Type Ia supernova SNF20080514-002. The data consist of 20 SuperNova Integral Field Spectrograph (SNIFS) spectra sampled over 50 days, commencing at 10 days before peak brightness. The analysis is part of a systematic effort to map out the time-dependent manifestation of ion species in Type Ia supernova spectra in detail. In general, the SN is relatively normal, but it possesses some noteworthy characteristics we explore in detail. C II footprints are detected in the spectra leading up to maximum light, suggesting that unburned material may be mixed with intermediate mass burning products. Though the light-curve qualifies as a moderately fast-decliner (s=0.87), its UV-optical colors are unusually blue. We attempt to place these findings into the ...
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