Type

Database

Creator

Date

Thumbnail

Search results

18,300 records were found.

The effect of wortmannin on IgG-receptor (FcyR)-mediated stimulation of human neutrophils was investigated. The Ca^(2+) influx induced by clustering of both Fcy receptors was inhibited by wortmannin, as was the release of Ca^(2+) from intracellular stores. Wortmannin also inhibited, with the same efficacy, the accumulation of Ins(1,4,5)P3 observed after FcyR stimulation, but did not affect the increase in Ins(1,4,5)P3 induced by the chemotactic peptide, formyl-methionine-leucine-phenylalanine. Because wortmannin is, in the concentrations used here, an inhibitor of PtdIns 3-kinase, these results suggested a role for PtdIns 3-kinase upstream of Ca^(2+) signalling, induced by FcyR cross-linking. Support for this notion was obtained by investigating the effect of another inhibitor of PtdIns 3-kinase, LY 294002, and by studying the kinetics...
This thesis is on light damage to the retina. Photochemical light damage to the retina can even occur under ambient light conditions as demonstrated by Noell et al. (1966) They found green light (500 nm) the most powerful in causing retinal damage. Under higher irradiance conditions the action spectrum changes: Short wavelengths are then the most harmful (Ham et al., 1979; Ham, Mueller and Sliney, 1982; Gorgels and van Norren, 1995). With ever increasing irradiance the domain of thermal damage is entered. The highest retinal irradiance used in the experiments in this thesis is approximately 300 mW/ cm . This is a rather high level, 2 but insufficient to increase the retinal temperature over 10 C; the generally accepted safety o limit (Ham et al., 1979). Another argument against thermal damage, is the duration of the exposure. Thermal d...
De juiste diagnose, classificatie en behandeling van thoraco-lumbale wervelfracturen blijven een problematisch en controversieël onderwerp in traumatologie. Een kort historisch overzicht (Hoofdstuk 1) laat zien dat de diagnose en behandeling van deze let-sels vaak hebben geleid tot hevige discussies en onenigheden. Voordat veilige en effectieve chirurgische technieken waren ontwikkeld, lag het centrum van de discussie in de vragen of een poging tot gesloten repositie iets toevoegde en hoe lang de rug geïmmobiliseerd moest worden. De huidige discussie wordt gedomineerd door de vraag welke letsels met welke benadering operatief behandeld dienen te worden. Geen consensus is nog bereikt over deze vragen aan het eind van de twintigste eeuw. Het lot van een patiënt met een gebroken rug hangt nog steeds af van de chirurgisch-culturele voork...
Abstract. In patients suffering from temporal lobe epilepsy (TLE) a highly variable degree of hippocampal sclerosis (HS) can be observed. For standard neuropathological evaluation after hippocampal resection, neuronal cell loss in the hippocampal subareas is assessed (Wyler score 0-4) [Wyler et al. (1992) J Epilepsy 5: 220-225]. Other marked morphological changes in the sclerotic hippocampus are gliosis and loss of mossy fibers in the hilus and mossy fiber sprouting in the supragranular layer. In this study we quantified changes in mossy fiber density using Timm's stain in resected hippocampal tissue from patients with various degrees of sclerosis. We found that tissue specimens from patients without sclerosis (W0) show almost no mossy fiber sprouting. Patients with moderate sclerosis show sprouting without fiber loss in the hilus, whe...
Want to know more?If you want to know more about this cutting edge product, or schedule a demonstration on your own organisation, please feel free to contact us or read the available documentation at http://www.keep.pt/produtos/retrievo/?lang=en