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Signal transduction pathways play important roles in cell differentiation, proliferation, and survival. Specific protein-protein interactions mediate the assemblies of protein complexes in response to different signals therefore regulate the proper transmission of cellular signals. Inappropriate protein-protein interactions within signalling pathways can lead to many diseases, including cancer. Proteomics-based approaches, which enable the quantitative investigation of protein-protein interactions involved in signalling networks, provide us with techniques to define the molecules controlling various signalling pathways. The small GTPase Rap1 belongs to the Ras family and shares high similarity with Ras protein. Rap1 cycles between an inactive GDP-bound state and an active GTP-bound state. This cycle is regulated by guanine nucleotide e...
Results on multi-lepton events at high transverse momenta, isolated lepton events with large missing transverse energy and single W production reported to this conference are based for the first time on the full data samples taken by two colliding experiments, H1 and ZEUS, at HERA. The data correspond to an integrated luminosity of about 1fb^-1 from both experiments.
The latest results from the e±p HERA collider both within the Standard (electroweak) Model and beyond are reviewed. Most of the results are based on the full HERA data sample, which corresponds to an integrated luminosity of about 0.5 fb−1 per experiment (H1 or ZEUS).
Physics from the polarized electron or positron beam colliding with the unpolarized proton beam at HERA-II as well as from the unpolarized ep collisions at HERA-I is discussed. Results shown include (i) inclusive neutral and charged current cross sections and structure functions measurements at HERA-I, (ii) the impact of these measurements on parton density functions, on electroweak parameters and searches for new physics and (iii) the first results at HERA-II and its future prospects.
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